ChemicalBook > CAS DataBase List > endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

Product Name
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
CAS No.
22235-81-0
Chemical Name
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms
YB-M2;Ipratropium Impurity E;N-Isopropylnoratropine;N-DesMethyl IpratropiuM;Ipratropium Bromide Impurity 13;Ipratropium Bromide EP Impurity E;NIsopropylnoratropine,N Isopropylnoratropine;Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E);Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine);N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)
CBNumber
CB6932642
Molecular Formula
C19H27NO3
Formula Weight
317.42258
MOL File
22235-81-0.mol
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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Property

Melting point:
112-114°C
Boiling point:
448.8±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.12±0.10(Predicted)
color 
White to Pale Orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18611
Product name
N-Isopropylnoratropine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18611
Product name
N-Isopropylnoratropine
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18611
Product name
N-Isopropylnoratropine
Purity
≥98%
Packaging
10mg
Price
$257
Updated
2024/03/01
TRC
Product number
I872680
Product name
N-IsopropylNoratropine
Packaging
50mg
Price
$580
Updated
2021/12/16
ApexBio Technology
Product number
C4093
Product name
N-Isopropylnoratropine
Packaging
10mg
Price
$291
Updated
2021/12/16
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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Orange Solid

Uses

N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.

Biological Activity

n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].

References

[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Suppliers

Canada 1 China 42 India 3 United States 7 Global 53
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
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58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14336
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58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58
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View Lastest Price from endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate 22235-81-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%+
Supply Ability
1T+
Release date
2024-03-08

22235-81-0, endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetateRelated Search:

(endo,anti)-(±)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide DL-TROPIC ACID Tropic acid Ipratropium bromide 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER Benzenepropanoic acid, b-oxo-a-phenyl-, methyl ester IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Atropine Impurity 4 Tropinone Atropine littorine (S)-Tropic acid Pseudotropine (1R,2R,4S,5S,7s,9S)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Atropine-d5 Atropine sulfate

  • endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
  • N-Isopropylnoratropine
  • rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester
  • N-DesMethyl IpratropiuM
  • α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester
  • α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester
  • Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E)
  • Ipratropium Impurity E
  • Ipratropium Bromide EP Impurity E
  • Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester
  • Ipratropium Bromide Impurity 13（Ipratropium Bromide EP Impurity E）
  • endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate
  • Ipratropium Bromide EP Impurity E (N-Isopropyl Noratropine)
  • N-Isopropyl Noratropine (Ipratropium Bromide EP Impurity E)
  • endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
  • YB-M2
  • NIsopropylnoratropine,N Isopropylnoratropine
  • (1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity)
  • Ipratropium Bromide Impurity 13
  • (1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
  • 22235-81-0
  • 2235-81-0
  • Aroamtics, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aroamtics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals